MUSCLE (3.7) multiple sequence alignment NC_002645_HCoV-229E_inf-1_nsp8_1 SVASSFVGMPSFVAYETARQEYENAVA---NGS-SPQIIKQLKKAMNVAKAEFDRESSVQ NC_005831_HCoV-NL63_AmsterdamI_n SVASSFVSMPSYIAYENARQAYEDAIA---NGS-SSQLIKQLKRAMNIAKSEFDHEISVQ NC_002306_TGEV_PUR46-MAD_nsp8_10 SVASAYAALPSWIALEKARADLEEAKK---NDV-SPQILKQLTKAFNIAKSDFEREASVQ NC_003436_PEDV_CV777_nsp8_11283. SVASTYVGLPSYVIYENARQQYEDAVN---NGS-PPQLVKQLRHAMNVAKSEFDREASTQ DQ811787_PRCV_ISU-1_nsp8_10966.. SVASAYAALPSWIALEKAHADLEEAKK---NDV-SPQILKQLTKAFNIAKSDFEREASVQ AY994055_FIPV_79-1146_nsp8_11057 SVASAYAALPSWIAYEKARADLEEAKK---NDV-SPQLLKQLTKACNIAKSEFEREASVQ NC_009657_BtCoV-G1_BtCoV/512/200 SVAATYVNLPSYLAYETARQSYEDALA---NGS-PPQLVKQLRHAMNVAKSEFDREASTQ EF203064_Bat-CoV-HKU2_HKU2/GD/43 SVASAFANMPSFIAYEKARMNYEDAIA---NDA-APAVVKQLKKAMNTAKGEFDHEASVQ NC_005147_HCoV-OC43_OC43_nsp8_11 ALQSEFVNMASFVEYEVAKKNLDEARF---SGSANQQQLKQLEKACNIAKSAYERDRAVA NC_006577_CoV-HKU1A_N1_nsp8_1224 ALQSEFVNMASFVEYEVAKKNLADAKN---SGSVNQQQIKQLEKACNIAKSVYERDKAVA AY884001_CoV-HKU1B_N2_nsp8_12149 ALQSEFVNMASFVEYEVAKKNLADAKN---SGSVNQQQIKQLEKACNIAKSVYERDKAVA DQ339101_CoV-HKU1C_N5_nsp8_12089 ALQSEFVNMASFVEYEVAKKNLADAKN---SGSVNQQQIKQLEKACNIAKSVYERDKAVA NC_003045_BCoV_BCoV-ENT_nsp8_119 ALQSEFVNMASFVEYEVAKKNLDEARS---SGSANQQQLKQLEKACNIAKSAYERDRAVA NC_001846_MHV_MHV-A59_nsp8_12255 ---SEFVNMASFVEYELAKKNLDEAKA---SGSANQQQIKQLEKACNIAKSAYERDRAVA NC_007732_PHEV_VW572_nsp8_11986. ALQSEFVNMASFVEYEVAKKNLDEARS---SGSANQQQLKQLEKACNIAKSAYERDRAVA EF424621_AntelopeCoV_US/OH1/2003 ALQSEFVNMASFVEYEVAKKNLDEARS---SGSANQQQLKQLEKACNIAKSAYERDRAVA EF424622_GiCoV_US/OH3-TC/2006_ns ALQSEFVNMASFVEYEVAKKNLDEARS---SGSANQQQLKQLEKACNIAKSAYERDRAVA NC_004718_SARS-human_Tor2_nsp8_1 AIASEFSSLPSYAAYATAQEAYEQAVA---NGD-SEVVLKKLKKSLNVAKSEFDRDAAMQ AY304488_SARS-civet_SZ16_nsp8_12 AIASEFSSLPSYAAYATAQEAYEQAVA---NGD-SEVVLKKLKKSLNVAKSEFDRDAAMQ NC_009694_SARS-bat_HKU3-1_nsp8_1 AIASEFSSLPSYAAYATAQEAYEQAVS---NGD-SEVVLKKLKKSLNVAKSEFDHDAAMQ AY545919_SARS-badger_CFB/SZ/94/0 AIASEFSSLPSYAAYATAQEAYEQAVA---NGD-SEVVLKKLKKSLNVAKSEFDRDAAMQ NC_009019_Bat-CoV-HKU4_B04f ATLTEFSHLATYAELETAQSSYQKALN---SGDASPQVLKALQKAVNVAKNAYEKDKAVA NC_009020_Bat-CoV-HKU5_LMH3f ATLSEFSHLASYAELEAAQSSYQKALN---SGDASPQVLKALQKAVNIAKNAYEKDKAVA NC_009021_Bat-CoV-HKU9_BF_005I AVASEFSNLSSYVDYENAQKAYDTAVA---TGA-PASTVNALKKAMNVAKSVLDKDVATT NC_001451_IBV_Beaudette_nsp8_109 SVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQ AY646283_IBV-partridge_Partridge SVTKEFSHIPSYAEYERAKDLYEKVLAESKNGGVTQQELAAYRKAANIAKSVFDRDLAVQ AY641576_IBV-peafowl_Peafowl/GD/ SVTQEFSHIPSYAEYERAKSIYEKVLADSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQ : :.:: *. . .. : .: * ** :.: : NC_002645_HCoV-229E_inf-1_nsp8_1 KKINRMAEQAAAAMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNMARNGVVP NC_005831_HCoV-NL63_AmsterdamI_n KKINRMAEQAATQMYKEARSVNRKSKVISAMHSLLFGMLRRLDMSSVETVLNLARDGVVP NC_002306_TGEV_PUR46-MAD_nsp8_10 KKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIDQARNGVLP NC_003436_PEDV_CV777_nsp8_11283. RKLDRMAEQAAAQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNLAKDGVVP DQ811787_PRCV_ISU-1_nsp8_10966.. KKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIDQARNGVLP AY994055_FIPV_79-1146_nsp8_11057 KKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIEQARNGVLP NC_009657_BtCoV-G1_BtCoV/512/200 RKLDRMAEQAASQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILSLAKDGVVP EF203064_Bat-CoV-HKU2_HKU2/GD/43 KKIQRMADAAAAQMYKDARAVDRKSKVVSAMHSLLFGMLRKLDMSSINQLMELAKDGCIP NC_005147_HCoV-OC43_OC43_nsp8_11 KKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP NC_006577_CoV-HKU1A_N1_nsp8_1224 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP AY884001_CoV-HKU1B_N2_nsp8_12149 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP DQ339101_CoV-HKU1C_N5_nsp8_12089 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP NC_003045_BCoV_BCoV-ENT_nsp8_119 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP NC_001846_MHV_MHV-A59_nsp8_12255 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP NC_007732_PHEV_VW572_nsp8_11986. RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP EF424621_AntelopeCoV_US/OH1/2003 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP EF424622_GiCoV_US/OH3-TC/2006_ns RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVP NC_004718_SARS-human_Tor2_nsp8_1 RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVP AY304488_SARS-civet_SZ16_nsp8_12 RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVP NC_009694_SARS-bat_HKU3-1_nsp8_1 RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVP AY545919_SARS-badger_CFB/SZ/94/0 RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVP NC_009019_Bat-CoV-HKU4_B04f RKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVIANARNGCVP NC_009020_Bat-CoV-HKU5_LMH3f RKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVISNARNGCVP NC_009021_Bat-CoV-HKU9_BF_005I RKLERMSELAMTAMYKQARAEDRRSKVTAAMQTMLFNMIRRLDSDALSNILNNARNGVVP NC_001451_IBV_Beaudette_nsp8_109 KKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVP AY646283_IBV-partridge_Partridge KKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVP AY641576_IBV-peafowl_Peafowl/GD/ KKLDSMAERTMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQANSGVVP .*:: *:: : : ***:** :..:*: ::::::** *:..:* . :. :: * .* :* NC_002645_HCoV-229E_inf-1_nsp8_1 LSVIPATSAARLVVVVPDHDSFVKMMVDGFVHYAGVVWTLQEVKDNDGKNVHLKDVTKE- NC_005831_HCoV-NL63_AmsterdamI_n LSVIPATSASKLTIVSPDLESYSKIVCDGSVHYAGVVWTLNDVKDNDGRPVHVKEITKE- NC_002306_TGEV_PUR46-MAD_nsp8_10 LSIIPAASATRLVVITPSLEVFSKIRQENNVHYAGAIWTIVEVKDANGSHVHLKEVTAA- NC_003436_PEDV_CV777_nsp8_11283. LSVIPAVSATKLNIVTSDIDSYNRIQREGCVHYAGTIWNIIDIKDNDGKVVHVKEVTAQ- DQ811787_PRCV_ISU-1_nsp8_10966.. LSIIPAASATRLVVITPSLEVFSKIRQENNVHYAGAIWTIVEVKDANGSHVHLKEVTAA- AY994055_FIPV_79-1146_nsp8_11057 LSIIPAASATRLIVVTPNLEVLSKVRQENNVHYAGAIWSIVEVKDANGAQVHLKEVTAA- NC_009657_BtCoV-G1_BtCoV/512/200 LSIIPAVSATKLNIVVSDIESYSKIQREGCVHYAGVIWSVVDIKDNDGKPVHAKEVVTS- EF203064_Bat-CoV-HKU2_HKU2/GD/43 MAIIPAAAATKLTVITPDLESFSKIRVDNNIYYAGAAWSITDVQDADGRVTILKEINAD- NC_005147_HCoV-OC43_OC43_nsp8_11 LNAIPSLAANTLNIIVPDKSVYDQVVDNVYVTYAGNVWQIQTIQDSDGTNKQLNEISDD- NC_006577_CoV-HKU1A_N1_nsp8_1224 LSAIPALAANTLTIVIPDKQVFDKVVDNVYVTYAGSVWHIQTVQDADGINKQLTDISVD- AY884001_CoV-HKU1B_N2_nsp8_12149 LNAIPALAANTLTIIIPDKQVFDKVVDNVYVAYAGSVWHIQTVQDADGINKQLTDISVD- DQ339101_CoV-HKU1C_N5_nsp8_12089 LSAIPALAANTLTIIIPDKQVFDKVVDNVYVTYAGSVWHIQTVQDADGINKQLTDISVD- NC_003045_BCoV_BCoV-ENT_nsp8_119 LNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAGNVWQIQTIQDSDGTNKQLNEISDD- NC_001846_MHV_MHV-A59_nsp8_12255 LNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQFIQDADGAVKQLNEIDVN- NC_007732_PHEV_VW572_nsp8_11986. LNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAGNVWQVQTIQDSDGTNKQLNEISDD- EF424621_AntelopeCoV_US/OH1/2003 LNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAGNVWQIQTIQDSDGTNKQLNEISDD- EF424622_GiCoV_US/OH3-TC/2006_ns LNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAGNVWQIQTIQDSDGTNKQLNEISDD- NC_004718_SARS-human_Tor2_nsp8_1 LNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD- AY304488_SARS-civet_SZ16_nsp8_12 LNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD- NC_009694_SARS-bat_HKU3-1_nsp8_1 LNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD- AY545919_SARS-badger_CFB/SZ/94/0 LNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD- NC_009019_Bat-CoV-HKU4_B04f LSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDITVINNVDNEVVKPTDVV-E- NC_009020_Bat-CoV-HKU5_LMH3f LSVVPLCASNKLRVVIPDITIWNKVVTWPSLSYAGALWDISLINNVDGEVVKSSDVT-E- NC_009021_Bat-CoV-HKU9_BF_005I LGVIPRTAANKLLLVVPDFSVYTATITMPTLTYAGSAWDVMQVADADGKTVNATDITRE- NC_001451_IBV_Beaudette_nsp8_109 LATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGSGL AY646283_IBV-partridge_Partridge LATVPIVCSNKLTLVVPDPETWVKCVEGMHVTYSTVVWNIDNVTDADGTELQPISTGNGL AY641576_IBV-peafowl_Peafowl/GD/ LATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDCVTDADGTELHPTSTGSGL : :* : * :: .. . *: * : : : :. . NC_002645_HCoV-229E_inf-1_nsp8_1 ----NQEILVWPLILTCER-----V-VKLQ NC_005831_HCoV-NL63_AmsterdamI_n ----NVETLTWPLILNCER-----V-VKLQ NC_002306_TGEV_PUR46-MAD_nsp8_10 ----NELNLTWPLSITCER-----T-TKLQ NC_003436_PEDV_CV777_nsp8_11283. ----NAESLSWPLVLGCER-----I-VKLQ DQ811787_PRCV_ISU-1_nsp8_10966.. ----NELNLTWPLSITCER-----T-TKLQ AY994055_FIPV_79-1146_nsp8_11057 ----NELNITWPLSITCER-----T-TKLQ NC_009657_BtCoV-G1_BtCoV/512/200 ----NVESLAWPLFLNCER-----I-IKLQ EF203064_Bat-CoV-HKU2_HKU2/GD/43 ----NKDALVWPLHVTCER-----V-VKLQ NC_005147_HCoV-OC43_OC43_nsp8_11 ----CN----WPLVIIANRYNEVSA-TVLQ NC_006577_CoV-HKU1A_N1_nsp8_1224 ----SN----WPLVIIANRYNEVAN-AVMQ AY884001_CoV-HKU1B_N2_nsp8_12149 ----SN----WPLVIIANRYNEVAN-AVMQ DQ339101_CoV-HKU1C_N5_nsp8_12089 ----SN----WPLVIIANRYNEVAN-AVMQ NC_003045_BCoV_BCoV-ENT_nsp8_119 ----CN----WPLVIIANRHNEVSA-TVLQ NC_001846_MHV_MHV-A59_nsp8_12255 ----ST----WPLVIAANRHNEVST-VVLQ NC_007732_PHEV_VW572_nsp8_11986. ----CN----WPLVIIANRHNEVSA-TVLQ EF424621_AntelopeCoV_US/OH1/2003 ----CN----WPLVIIANRHNEVSA-TVLQ EF424622_GiCoV_US/OH3-TC/2006_ns ----CN----WPLVIIANRHNEVSA-TVLQ NC_004718_SARS-human_Tor2_nsp8_1 ----NSPNLAWPLIVTALR--ANSA-VKLQ AY304488_SARS-civet_SZ16_nsp8_12 ----NSPNLAWPLIVTALR--ANSA-VKLQ NC_009694_SARS-bat_HKU3-1_nsp8_1 ----NSPNLAWPLIVTALR--ANSA-VKLQ AY545919_SARS-badger_CFB/SZ/94/0 ----NSPNLAWPLIVTALR--ANSA-VKLQ NC_009019_Bat-CoV-HKU4_B04f ----TNESLTWPLVIECSR-SSSSA-VKLQ NC_009020_Bat-CoV-HKU5_LMH3f ----TNESLTWPLVLECTR-AASSA-VTLQ NC_009021_Bat-CoV-HKU9_BF_005I ----NSVNLAWPLVVTAQRQQATSP-VKLQ NC_001451_IBV_Beaudette_nsp8_109 TYCISGANIAWPLKVNLTRNGHNKVDVVLQ AY646283_IBV-partridge_Partridge TYCISGDTIAWPLKVTLTRNAHNKVDAVLQ AY641576_IBV-peafowl_Peafowl/GD/ TYCISGDNIAWPLKVNLTRNGHNKVDVALQ *** : * :*